How to Stop Nausea in Dogs: Effective Remedies and Tips
Nausea in dogs can be distressing for both the animal and the pet owner. It commonly occurs during travel or due to medical conditions such as vestibular disease. Fortunately, there are several treatments and preventive measures that can help relieve nausea in dogs, the most prominent being the use of Dramamine.
What Is Dramamine and How Does it Work?
Dramamine, also known as dimenhydrinate, is an antihistamine widely used to treat motion sickness in dogs. It works by blocking histamine receptors in the brain, which helps alleviate symptoms such as:
- Nausea
- Vomiting
- Excessive drooling
- Restlessness
- Whining
- Panting and yawning
- Discomfort during travel
While primarily developed for humans, veterinarians often prescribe it off-label for dogs to manage travel-induced nausea or motion-related sickness.
How to Administer Dramamine
Dramamine comes in forms such as regular tablets, chewable tablets, and oral liquid. Administer it orally, with or without food. Giving it with a treat may reduce the chance of stomach upset. For optimal effectiveness during travel, give it to your dog 30 to 60 minutes prior to departure.
Typical dosage is 2 to 4 mg per pound of body weight every eight hours or as advised by a vet. General examples are:
- Small dogs: 25 mg
- Large dogs: 50 mg
Always verify dosages with a veterinarian and avoid using combination products or “non-drowsy” formulas that may include unsafe ingredients like ginger or other medications.
Possible Side Effects
While Dramamine is generally safe, it can cause side effects, including:
- Sleepiness or sedation
- Dry mouth
- Increased thirst
- Difficulty urinating
- Reduced appetite
- Vomiting or diarrhea
- Rare cases: hyperactivity, seizures, or coma (with overdose)
Immediate veterinary attention is required if you notice signs of an allergic reaction such as swelling of the face, hives, or difficulty breathing.
Health Conditions That Require Caution
Consult your vet before using Dramamine in dogs with the following conditions:
- Seizures
- Glaucoma
- Overactive thyroid
- Heart problems or high blood pressure
- Asthma or other respiratory disorders
- Gastrointestinal or urinary blockage
- Enlarged prostate
Do not use in puppies, lactating females, or within two weeks of an allergy skin test.
Drug Interactions
Dramamine may interact adversely with various medications. Inform your vet about all substances your dog is taking, especially:
- Other antihistamines
- Muscle relaxants
- Sedatives
- Antidepressants
- Benzodiazepines (like lorazepam or diazepam)
- Anti-seizure drugs
- Opioids and anticholinergic medications
Alternatives to Dramamine
If Dramamine isn’t suitable or effective, alternative treatments include:
- Other antihistamines: diphenhydramine (Benadryl), chlorphenamine, or cetirizine
- Prescription medications: maropitant citrate (Cerenia), trazodone, gabapentin
- Behavioral adjustment: Training and acclimation to travel
- Calming wraps and travel planning
- Herbal options like ginger (used with vet guidance)
Practical Tips for Administration and Storage
- If you miss a dose, give it as soon as remembered, but never double-dose
- Store at room temperature; do not freeze liquid
- Watch for adverse reactions upon initial use
In cases of potential overdose, contact a veterinary emergency center immediately.
When to Consult a Veterinarian
- Before initiating any medication
- If your dog is elderly, pregnant, or has pre-existing conditions
- To verify accurate dosages
- When side effects occur
Dramamine can be effective in managing canine nausea, especially for travel. For best results, use it as part of a larger strategy, including environmental controls and proper planning.





