How to Manage and Treat Hyperkeratosis in Dogs
Hyperkeratosis is a chronic skin condition in dogs where an excessive amount of keratin is produced, leading to thick, crusty, and often painful patches, primarily on the paw pads and nose. These thickened areas can crack, bleed, and become infected if not properly managed. While there is no permanent cure for hereditary forms, the condition can be effectively managed to ensure your dog stays comfortable and active.
Common Causes of Hyperkeratosis
- Genetics: Certain breeds are predisposed, including Bulldogs, Boxers, and Beagles.
- Age: Older dogs may develop age-related hyperkeratosis due to pressure calluses and skin changes.
- Autoimmune diseases: Conditions like pemphigus foliaceus can trigger keratin buildup.
- Infectious diseases: Viral illnesses such as canine distemper can cause skin thickening.
- Nutrition: Zinc deficiency or poor absorption can lead to skin abnormalities, particularly in large breed puppies.
Recognizing the Symptoms
- Hardened, crusty areas on the nose or paw pads
- Cracks, bleeding, or ulceration
- Leaf- or hair-like projections from affected skin
- Lameness, limping, or discomfort while walking
- Increased licking or chewing at the affected areas
- Loss of skin pigmentation, often appearing pink
Diagnosis and Veterinary Assessment
A veterinary examination is essential. Tests may include:
- Bloodwork and urinalysis to identify systemic or autoimmune disease
- Skin scrapings or biopsy to evaluate for infections or cancer
- Clinical evaluation to determine the severity
Effective Treatment Strategies
While hereditary hyperkeratosis cannot be cured, it can be managed with a combination of topical treatments, diet, and veterinary care.
1. Topical Treatments
- Keratolytic agents such as salicylic acid or urea help loosen and remove excess skin.
- Moisturizing balms or ointments soften and protect the affected areas.
2. Physical Management
- Trimming or filing thickened skin by a professional
- Soaking paws in warm water or Epsom salt solutions to soften keratin before applying treatments
3. Treating Infections
- Topical or oral antibiotics or antifungal medications when infection is present
4. Dietary Support
- Diets rich in zinc and omega-3 fatty acids can improve skin health
- Veterinary consultation for supplements if needed
5. Addressing Underlying Conditions
- If due to autoimmune or infectious causes, immunosuppressants or antiviral medications may be required
Prevention and Long-Term Care
- Regular inspection of your dog’s paws and nose
- Use of pad moisturizers during dry weather or on rough terrain
- Clean, cushioned bedding to minimize callus formation
- Balanced diet with necessary nutrients
- Vaccination and parasite prevention against diseases like distemper and leishmaniasis
Though hereditary hyperkeratosis is a lifelong condition, most dogs can lead a normal life with proper care. Routine vet visits and a good skincare regimen can keep complications at bay and improve your dog’s comfort.
When to See the Vet
Consult your veterinarian if you notice:
- Sudden changes on the nose or paw pads
- Persistent discomfort or lameness
- Cracks with signs of infection like swelling or discharge
Early intervention can prevent complications and lead to better outcomes in managing hyperkeratosis.





