Is Dramamine Safe for Dogs? What Every Pet Owner Should Know
If your dog gets carsick or anxious during travel, you might wonder if Dramamine is a safe solution. Dramamine, also known as dimenhydrinate, is an antihistamine frequently used to treat and prevent motion sickness in dogs. But before you reach for this medication, it's important to understand how it works, how to use it safely, and what precautions you should take.
What Is Dramamine and Why Use It for Dogs?
Dramamine is primarily an antihistamine designed for humans, but veterinarians often recommend it off-label to manage motion sickness in dogs. This means it's not specifically approved for animals by the FDA, but its use in pets is common practice.
- Helps with symptoms: nausea, vomiting, excessive drooling, whining, panting, yawning, restlessness, and general discomfort during travel.
- Sometimes used for vestibular disease in older dogs (a condition affecting balance and the inner ear).
You'll find Dramamine as regular tablets, chewable tablets, or oral liquid. There are no pet-specific versions; human formulations are used instead.
How to Give Dramamine Safely
The typical dosage ranges from 2 to 4 mg per pound of body weight every 8 hours, but always confirm the dose with your vet—especially for small dogs under six pounds. Tablets can be given with or without food; pairing them with a treat may help avoid stomach upset. For best results during travel, give the dose 30–60 minutes before departure.
- Only use products with dimenhydrinate as the sole active ingredient.
- Avoid combination or "non-drowsy" formulas that may contain other substances like ginger.
Possible Side Effects in Dogs
Most dogs tolerate Dramamine well. The most common side effect is drowsiness or sedation—which might actually help anxious travelers relax. Other potential side effects include:
- Dry mouth and increased thirst
- Trouble urinating
- Decreased appetite
- Mild stomach upset (vomiting or diarrhea)
- (Rarely) hyperactivity
An overdose could cause seizures or even coma. Allergic reactions are possible too; watch for facial swelling, hives, or breathing trouble—these require immediate veterinary attention.
When Not to Use Dramamine
Certain health conditions make Dramamine risky or unsuitable:
- Glaucoma
- Seizure disorders
- Overactive thyroid gland
- Heart disease or high blood pressure
- Liver problems
- Enlarged prostate or urinary/gastrointestinal blockage
- Respiratory issues like asthma
Avoid giving it to puppies (neonatal dogs), those allergic to antihistamines, or within two weeks before allergy skin testing. Nursing and elderly dogs may tolerate it but still need close monitoring.
Drug Interactions: What Else Is Your Dog Taking?
Dramamine can interact with other medications—especially:
- Sedatives and muscle relaxants
- Benzodiazepines (e.g., diazepam)
- Opioids and antidepressants
- Anti-seizure drugs and anticholinergics
If your dog takes any other medicine or supplement—even herbal remedies—let your vet know before starting Dramamine.
If You Miss a Dose or Suspect an Overdose
- If you forget a dose: Give it as soon as you remember unless it's almost time for the next scheduled dose—never double up.
- If you suspect an overdose: Contact your veterinarian or an emergency animal hospital right away.
Dramamine Alternatives for Dogs Who Can't Tolerate It
If your dog doesn't respond well to Dramamine—or can't take it due to health reasons—there are alternatives:
- Cetirizine (Zyrtec), diphenhydramine (Benadryl), chlorphenamine: other antihistamines sometimes used off-label in dogs.
- Cerenia (maropitant citrate): prescription anti-nausea medication specifically for pets.
- Trazodone or gabapentin: prescription medications that can help with anxiety related to travel.
You can also try non-drug methods such as gradual acclimation to car rides, calming wraps (like Thundershirts), behavioral training techniques, and certain herbal supplements like ginger—if approved by your vet.
The Bottom Line: Always Involve Your Veterinarian
Dramamine can be part of a comprehensive approach to managing motion sickness in dogs—but it's not a one-size-fits-all solution. Always consult your veterinarian before giving any new medication to your pet. Monitor closely for side effects when starting treatment and never exceed recommended doses. With proper guidance and care, many dogs enjoy safer and less stressful journeys alongside their humans.
