Understanding Feline Calicivirus in Cats
Feline calicivirus (FCV) stands out as one of the most common and troublesome viral pathogens affecting cats around the world. Whether you have a single pet or manage a bustling shelter, knowing about this virus is crucial for your cat's health and well-being.
What Is Feline Calicivirus?
FCV is a small, non-enveloped, single-stranded RNA virus belonging to the Caliciviridae family. Its high mutation rate means there are many different strains circulating at any given time. This genetic variability complicates both prevention and treatment—it's why outbreaks can be persistent and sometimes hard to control.
The virus primarily targets the upper respiratory tract and the mouth, but its symptoms can range widely depending on the strain involved and your cat's immune status.
How Common Is FCV?
This virus is widespread. Studies show up to 13% of pet cats carry FCV, with prevalence soaring to 85% in some crowded colonies or shelters. It's especially problematic where lots of cats live together or where hygiene isn't ideal.
How Does FCV Spread?
- Direct contact: The main way FCV spreads is through oral and nasal secretions—think sneezing, grooming, or sharing food bowls.
- Indirect transmission: Objects like toys, bedding, litter boxes, or even human hands can carry infectious particles from one cat to another.
- Carrier state: Some cats become long-term carriers after infection (sometimes for life), shedding the virus even if they appear perfectly healthy.
The risk of an outbreak increases dramatically with more cats in a group. Shelters, catteries, and multi-cat households are particularly vulnerable.
Who Is Most at Risk?
- Kittens: Young cats are especially susceptible.
- Unvaccinated cats: Without vaccination, the chances of infection rise sharply.
- Cats under stress: Stress weakens immune defenses—crowding, new arrivals, or environmental changes all play a part.
If you bring a new cat into your home or shelter, both the newcomer and resident felines face increased risk during the adjustment period.
Symptoms: What Does FCV Look Like?
The clinical signs of FCV infection vary widely. Not every infected cat will show symptoms; some remain silent carriers. When illness does occur, it may include:
- Sneezing and nasal discharge: Ranging from clear to yellow-green mucus.
- Eye problems: Watery or mucopurulent ocular discharge; conjunctivitis; rarely corneal ulcers.
- Painful oral ulcers: Especially on the tongue, palate, lips, or nose—these are classic for FCV. Cats may drool excessively or refuse food because it hurts to eat.
- Gingivitis/stomatitis: Chronic inflammation of gums and mouth lining (feline chronic gingivostomatitis) can develop in some cases.
- Lameness (limping syndrome): Transient joint pain causing shifting lameness—seen mostly in kittens or after certain vaccinations; usually resolves quickly.
- Virulent systemic disease: Rarely, highly aggressive strains cause severe illness: high fever, swelling of face/limbs, jaundice, skin ulcers, pneumonia, organ failure. These outbreaks have high fatality rates (30-70% or more), mainly affecting adults.
The severity depends on viral strain differences, co-infections (like feline herpesvirus), host immunity, and stress levels. Most cases resolve without major complications—but when aggressive strains hit stressed populations, consequences can be dire.
Diagnosing FCV Infection
Your veterinarian will usually suspect FCV based on clinical signs—especially if painful mouth ulcers are present. To confirm infection:
- PCR testing: Swabs from mouth/nose/eyes detect viral RNA reliably.
- Virus isolation: Less commonly performed but definitive when available.
- Serology: Rarely used except for research purposes.
A challenge: Healthy carriers and vaccinated cats may test positive too! Results always need interpretation alongside symptoms and history—tests can't distinguish between mild and virulent strains by sequence alone.
Treatment Options for FCV
No specific antiviral exists for FCV yet. Treatment focuses on supportive care to help your cat recover comfortably:
- Nutritional support: Encourage eating; use appetite stimulants or feeding tubes if necessary.
- Pain relief: Non-steroidal anti-inflammatories (with caution).
- Treat secondary infections: Antibiotics like doxycycline if bacterial co-infection is suspected.
- Nasal decongestion: Steam therapy or nebulization helps breathing comfort.
- Eye care: Topical antibiotics for conjunctivitis/eye discharge as needed.
- Mouth care: Dental cleaning/chlorhexidine rinses; sometimes full-mouth extractions for severe chronic cases (FCGS).
If dehydration or inability to eat becomes severe—or if systemic disease develops—hospitalization might be required. In outbreaks involving virulent systemic strains (VS-FCV), intensive care may help but prognosis remains guarded.
Prevention Strategies
- Vaccination: This is your best defense. Vaccines are considered core for all cats and reduce disease severity plus viral shedding duration (but don't guarantee complete protection).
- Kittens start vaccines at 8-9 weeks old, with boosters at 12 & 16 weeks, then again at 10-16 months. Adults get two doses (2-4 weeks apart) if unvaccinated, plus annual boosters thereafter (then every 1-3 years based on risk).
- Hygiene & disinfection: Bleach-based solutions work best (1:32 household bleach). Clean surfaces/toys/litter boxes regularly, especially during outbreaks. The virus resists many disinfectants but succumbs to bleach. It survives on dry surfaces up to a month!
- Isolation/quarantine: New arrivals should be separated for at least 2-3 weeks before joining other cats. This helps break transmission cycles. Reduce crowding & stress wherever possible. Avoid unnecessary movement between groups.
Zoonotic Risk?
No need to worry about catching this from your pet—feline calicivirus is species-specific; it doesn't infect humans or other non-feline animals.
The Takeaway
- Cats with FCV usually recover in 1-3 weeks; a few become chronic carriers at risk for oral disease later on.
- Mild cases predominate, but serious outbreaks do happen (especially with virulent strains).





