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Why has my cat still got fleas after using Frontline?

Fleas seen after using Frontline are typically new pests from the environment and are killed within 24 hours; monthly use is needed to fully break the flea life cycle.

Why Your Cat Still Has Fleas After Using Frontline: Explained

Many cat owners are surprised to discover fleas on their pets even after administering flea treatments like Frontline Plus. This situation can be frustrating, but understanding how flea treatments work—and what they don’t do—can help clarify why your cat may still host a few unwanted visitors after application.

Understanding How Frontline Plus Works

Frontline Plus for Cats contains two active ingredients:
  • Fipronil – Kills adult fleas and ticks by disrupting their central nervous systems. Fleas typically die within 24 hours, and ticks within 48 hours.
  • (S)-Methoprene – An insect growth regulator that halts the development of flea eggs, larvae, and pupae, effectively breaking the flea life cycle.
After topical application, the treatment spreads over the skin and coat through natural skin oils and sebaceous glands. This ensures continuous protection, even after exposure to water post the first 24 hours.

Why Fleas May Still Be Visible

Seeing fleas after treatment doesn’t necessarily mean the product isn’t working. Here’s why:
  • New fleas can jump on from the environment even after treatment. These are usually killed within 24 hours.
  • The flea life cycle involves multiple stages: adult, egg, larva, and pupa. Frontline Plus kills adults quickly and prevents immature life stages from developing, but pupae can remain dormant and emerge later.
  • Just one application isn’t enough to eliminate a home infestation. Monthly use is critical to gradually kill off each generation.

Proper Application Techniques Are Crucial

Incorrect application may reduce effectiveness. Follow these key steps:
  • Part the fur at the base of the neck between the shoulders to expose skin.
  • Apply the full pipette contents directly onto the skin—not the fur.
  • Don’t let the cat lick the area, and avoid touching it until completely dry (usually 24 hours).
  • Refrain from bathing the cat within 24–48 hours post-application.
  • Prevent cats from grooming each other until the site has dried.

Consistency Is Key

Applying Frontline Plus once per month year-round gives your cat the best defense. Fleas can survive indoors thanks to central heating and warm climates. Some tick species remain active in colder temperatures, so ongoing protection is essential.

Treat the Household, Not Just the Cat

Flea infestations can persist because of untreated environments. Even if the fleas on your pet die, new ones can hatch from:
  • Carpets
  • Furniture
  • Pet bedding
  • Cracks and crevices in floors or walls
Follow these steps to combat a home infestation:
  1. Vacuum regularly—especially where your pet lounges.
  2. Wash pet bedding and soft furnishings frequently in hot water.
  3. Treat all pets in the household simultaneously to stop cross-contamination.
  4. Use environmental sprays if necessary, or enlist professional pest control for severe infestations.

Check for Safety and Suitability

Ensure you’re using Frontline Plus specifically formulated for cats. Never use products intended for dogs, as the concentrations can be harmful. Frontline Plus is safe for most cats, including pregnant or lactating females. However, reactions, although rare, may occur. Watch for:
  • Itching or redness at application site
  • Hair loss
  • Drooling if licked
  • More severe symptoms like vomiting or tremors—seek veterinary care immediately if observed

Fleas on Indoor Cats?

Yes, even indoor-only cats can get fleas. Fleas may hitchhike into your home via:
  • Other pets
  • Humans’ clothing or shoes
  • Infested furniture or rugs
If your indoor cat has fleas, apply Frontline Plus as directed and treat your living space just as you would for an outdoor pet.

The Takeaway

If you spot fleas shortly after using Frontline Plus, don't panic—it's part of the process. As long as the product is applied correctly and administered monthly, it will kill adult fleas and prevent their offspring from developing, effectively controlling infestations over time. To support the efficacy of topical flea treatments:
  • Maintain a consistent application schedule
  • Treat all animals in the household
  • Address environmental flea sources
With patience and diligence, you can achieve long-term flea control and keep your feline friend itch-free.

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