Proper Dosage of 25 mg Dramamine for Dogs
Dramamine, also known by its generic name dimenhydrinate, is an over-the-counter antihistamine commonly used to treat motion sickness in dogs. Whether you're planning a car trip, boat ride, or air travel, Dramamine can help alleviate your dog’s nausea, vomiting, and dizziness. However, correct dosing is essential to ensure both safety and effectiveness.
Understanding Dramamine and Its Uses
Dramamine’s active ingredient works by blocking signals in the brain that lead to symptoms of motion sickness. In dogs, it’s mostly used for:
- Preventing motion-related nausea and vomiting
- Treating vestibular disease in older dogs
- Calming restlessness, drooling, and panting during travel
Though the drug is FDA-approved for human use only, off-label use in veterinary care is a common and accepted practice. Always consult your veterinarian before giving your dog any new medication.
How Much 25 mg Dramamine Can I Give My Dog?
The typical dosage of Dramamine for dogs is 2 to 4 mg per pound of body weight, administered every 8 hours.
You can calculate the proper dose as follows:
- 10 lb dog = 20–40 mg per dose (usually 1 tablet of 25 mg is appropriate)
- 25 lb dog = 50–100 mg per dose (2 tablets may be suitable)
- 50 lb dog = 100–200 mg per dose (4 tablets, depending on vet confirmation)
Always round down if you're unsure, and consult your vet, especially for small dogs weighing under 6 pounds.
Forms and Administration
Dramamine is available in several forms:
- Regular tablets (25 mg)
- Chewable tablets
- Oral liquids
Administer the medication 30 to 60 minutes before traveling for best results. You can give it with or without food, but pairing with a small meal can help avoid stomach issues.
Precautions and Contraindications
Though many dogs tolerate Dramamine well, certain conditions and drugs may pose risks:
- Avoid in dogs with glaucoma, seizures, heart disease, or urinary issues
- Not recommended for very young puppies, neonatal dogs, or dogs undergoing allergy testing
- Use cautiously in older dogs, nursing mothers, and dogs with thyroid or respiratory problems
Potential Side Effects
- Drowsiness (most common)
- Dry mouth, increased thirst
- Decreased appetite or mild stomach upset
- Seizures or coma in overdose scenarios
- Allergic reactions, including facial swelling and breathing difficulties
If side effects occur, stop use immediately and consult your veterinarian.
Drug Interactions
Inform your vet if your dog is on any of the following before administering Dramamine:
- Other antihistamines (e.g., Benadryl)
- Sedatives, muscle relaxants, antidepressants
- Anti-seizure or anticholinergic medications
- Opioids or benzodiazepines (e.g., diazepam)
Alternatives to Dramamine
If Dramamine isn’t effective or well tolerated, consider the following:
- Other antihistamines: cetirizine, diphenhydramine, chlorphenamine
- Prescription meds: maropitant citrate (Cerenia), trazodone, gabapentin
- Natural options: ginger, calming wraps, behavioral therapy
Storage and Overdose
- Store at room temperature. Avoid freezing liquid forms.
- In case of accidental overdose, contact a veterinary emergency clinic immediately.
Final Recommendations
Dramamine can be a helpful solution for travel-anxious dogs, but veterinary guidance is crucial to determine the correct dose and monitor for potential side effects. Start with the lowest effective dose and stay alert to any behavioral or physical changes after administration.





