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How to test for pillow foot in cats?

Testing for pillow foot in cats involves clinical examination of paw pads, cytology or biopsy to detect plasma cells, and blood tests including FIV and FeLV screening.

How to Test for Pillow Foot in Cats

Feline plasma cell pododermatitis, commonly referred to as pillow foot, is a rare but treatable skin condition in cats. It primarily affects the paw pads, leading to swelling, softness, and discoloration. Accurate and timely diagnosis is crucial to implement effective treatment and ensure comfort for your feline companion. This article explores how veterinarians test for pillow foot, what symptoms to look out for, and why proper diagnosis is essential.

Recognizing the Symptoms

Pet owners should be aware of the characteristic signs of pillow foot to prompt early veterinary consultation. The most common symptoms include:
  • Swollen, soft, and mushy paw pads
  • Discoloration — pads may appear deep pink or purple with white striations
  • Painful ulcers or open sores, especially in advanced cases
  • Lameness or limping
  • Involvement of multiple footpads, especially the metacarpal and metatarsal pads
Additional but less common signs may involve:
  • Swelling at the bridge of the nose
  • Stomatitis (gum inflammation)
  • Upper respiratory infections
  • Fevers or loss of appetite

Initial Clinical Examination

Veterinarians begin with a thorough physical examination of the affected paws. Pillow foot presents with a distinctive clinical appearance:
  • Soft and sponge-like texture of swollen pads
  • Discoloration ranging from reddish to purplish hues
  • Potentially affecting multiple limbs simultaneously

Diagnostic Testing Methods

To confirm a diagnosis of pillow foot and rule out other conditions, veterinarians employ several minimally invasive tests:
  1. Fine-Needle Aspiration (FNA) Cytology: A needle is used to collect cells from the swollen pad. These are examined under a microscope for an abundance of plasma cells.
  2. Biopsy: A tissue sample from the affected pad may be surgically removed and analyzed histologically to determine the presence of lymphocyte and plasma cell infiltration.
  3. Blood Tests: Standard blood panels often reveal:
    • Increased globulin levels
    • Alterations in lymphocyte counts
  4. Viral Screening:
    • Feline Immunodeficiency Virus (FIV): 44–63% of affected cats test positive
    • Feline Leukemia Virus (FeLV): Screened as a potential trigger or contributing factor

Ruling Out Other Conditions (Differential Diagnosis)

Since other ailments can cause similar swelling, veterinarians ensure to exclude them through careful assessments:
  • Tumors — which usually affect one pad
  • Insect bites or stings
  • Bacterial or fungal infections
  • Eosinophilic granuloma complex

Importance of Early and Accurate Diagnosis

Prompt diagnosis allows for earlier treatment, preventing the condition from progressing to discomfort, pain, or ulceration. Early intervention also minimizes the need for invasive treatments such as surgery.

Treatment Path Following Diagnosis

Once pillow foot is confirmed through diagnostic testing, treatment typically involves:
  • Oral Doxycycline: Offers both antibiotic and immunomodulatory effects. It is a first-line treatment with successful results in around 50% of felines after two months.
  • Glucocorticoids: Options like prednisolone are used if doxycycline isn’t effective.
  • Cyclosporine: An immunosuppressant used in resistant cases.
  • Surgical Excision: Required in severe or non-responsive ulcerative cases.
Veterinarians aim to alleviate inflammation and control the overactive immune response attacking the paw tissue.

Prognosis and Ongoing Monitoring

The prognosis for cats diagnosed with pillow foot is generally positive. Many go into remission with appropriate treatment. However, some might experience relapses, necessitating periodic medication or adjustment in therapy. Owners should schedule regular veterinary follow-ups to monitor for:
  • Treatment efficacy
  • Side effects of long-term medication
  • Signs of recurrence
In rare complications, such as immune-mediated glomerulonephritis or amyloidosis, the condition may turn severe, which reinforces the need for vigilant monitoring.

Conclusion

Testing for pillow foot in cats is a multi-step yet straightforward process that includes visual inspection, cytology or biopsy, and blood testing. Prompt and accurate diagnosis ensures that affected cats receive the right care and have a good chance of recovery. If you notice unusual changes in your cat’s paws, consult a veterinarian without delay for the best outcomes.

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