Understanding Feline Panniculitis: Causes, Symptoms, and Treatment
Panniculitis is an inflammatory condition affecting the subcutaneous fat tissue in cats. Though it is relatively uncommon, recognizing and addressing this condition is essential due to the discomfort and potential complications it can cause for your pet. This article covers the causes, symptoms, diagnostic methods, treatment options, and preventive steps for cat owners.
What Is Panniculitis?
Panniculitis refers to an inflammation of the fat layer beneath the skin. It usually manifests as deep, firm swellings or nodules which may rupture and release an oily, yellowish, or bloody discharge. These nodules are typically located on the trunk or abdomen but can appear anywhere on the body.
Common Causes
The etiology of panniculitis is multifactorial, meaning that several underlying issues could lead to the condition. Some common causes include:
- Trauma: The most frequent cause, especially if a single lump is present. Examples include bite wounds or injections.
- Infections: Bacterial (e.g., Staphylococcus, Mycobacterium), fungal (e.g., Sporothrix), or parasitic agents.
- Immune-mediated diseases: Like lupus panniculitis or other autoimmune disorders.
- Neoplastic conditions: Certain cancers might be involved.
- Vitamin E deficiency: Particularly with poorly balanced or fish-based diets.
- Pancreatitis and blood supply disorders
- Drug reactions: Post-injection-related panniculitis is relatively common.
Signs and Symptoms
Panniculitis can present in various ways. The most common signs include:
- One or multiple firm subcutaneous nodules
- Nodules that ulcerate or rupture, resulting in drainage of yellow or bloody fluid
- Overlying skin may change color (red, brown, or yellow)
- Formation of crusts or scars post-rupture
- Systemic signs such as fever, lethargy, depression, and loss of appetite
- Permanent alopecia in affected areas
Diagnosing Panniculitis
Veterinarians adopt a methodical approach in diagnosing panniculitis, including:
- Detailed history and physical exam
- Fine needle aspiration (FNA) or biopsy for cytology and histopathology
- Blood tests: Complete blood count and biochemistry profile
- Imaging: Radiographs or ultrasounds to assess for internal causes
- Culture and sensitivity testing to identify infectious organisms
Treatment Options
The treatment plan depends on whether the panniculitis is infectious or non-infectious:
1. Infectious Panniculitis
- Antimicrobials targeted to the identified bacteria or fungi
- Mycobacterial infections require long-term antibiotics like doxycycline, fluoroquinolones, or clarithromycin
- Surgical removal of affected tissues is often necessary for localized infections
- Perioperative antibiotics to prevent recurrence
2. Non-Infectious Panniculitis
- Immunosuppressive therapy: Glucocorticoids such as prednisolone are commonly used
- In resistant cases, drugs like cyclosporine or tacrolimus may be added
- Combinations like tetracycline and niacinamide could be helpful
- Vitamin E supplements for suspected dietary deficiency
Will It Go Away on Its Own?
While some mild cases might improve, panniculitis usually does not resolve by itself. Without appropriate treatment, lesions may worsen or recur, and systemic symptoms can develop. Identifying and treating the root cause is essential for recovery.
Prognosis and Long-Term Management
With timely and appropriate intervention, the prognosis is generally good. However, chronic or recurring cases—especially those stemming from systemic disease—require ongoing management. Follow-up appointments are essential to monitor for new lesions or complications.
Preventive Measures
Although it’s not always possible to prevent panniculitis, several steps can greatly reduce risks:
- Keep cats indoors to limit trauma risks
- Maintain a balanced diet and consider vitamin E supplementation if needed
- Administer injections properly and use sterile techniques
- Prompt veterinary attention for wounds or unusual skin changes
- Protect against exposure to infectious agents
Conclusion
Feline panniculitis is a complex condition involving inflammation of subcutaneous fat. Whether caused by trauma, infection, immune dysfunction, or dietary issues, it typically requires professional veterinary treatment. Through proper diagnosis, targeted therapy, and continuous monitoring, most cats can enjoy a full recovery and improved quality of life.





