Understanding the FeLV Vaccine: Protecting Your Cat from Feline Leukemia
The FeLV vaccine is a crucial tool in feline preventative healthcare. Feline leukemia virus (FeLV) is a contagious and potentially fatal virus that affects only cats. The virus suppresses the immune system, leaving cats vulnerable to infections, anemia, and various cancers, most notably lymphoma. Vaccination greatly reduces the risk of persistent infection and serious disease.
Why Is the FeLV Vaccine Important?
FeLV is widespread globally and primarily spreads through exchange of bodily fluids. Here’s why vaccinating against FeLV matters:
- Immune suppression: FeLV weakens a cat’s immune system, making everyday pathogens life-threatening.
- Transmission routes: It’s spread via grooming, biting, shared bowls, and from mother to kittens during birth or nursing.
- No cure: Once FeLV establishes in the bone marrow, cats remain infected for life.
- Shortened lifespan: Most persistently infected cats live less than three years after diagnosis.
Who Should Be Vaccinated?
- Kittens: All should receive their initial vaccine between 8–12 weeks old.
- Outdoor cats: Cats that go outside or interact with other felines have higher exposure risk.
- Multi-cat households: Especially when the FeLV status of all cats isn’t known.
- Indoor-only adult cats: May not need vaccination after the initial kitten series unless their exposure risk changes.
Vaccine Protocol
- Initial vaccination: Two doses given 3–4 weeks apart beginning at 8–12 weeks of age.
- Booster recommendations: Annual boosters for at-risk cats; low-risk indoor cats may not require them regularly.
- Pre-vaccination testing: FeLV blood testing (ELISA) is recommended to confirm a cat's status before administering the vaccine.
Effectiveness of the FeLV Vaccine
FeLV vaccination has proven highly effective in protecting cats. Some clinical studies report over 85% effectiveness in preventing persistent infection. Newer RNA-particle vaccines offer protection for up to two years after the initial series.
Risks and Side Effects
As with any medical intervention, FeLV vaccination carries minimal risks. Common side effects are mild and short-lived:
- Soreness at the injection site
- Lethargy or mild fever that resolves in 24–48 hours
In extremely rare cases, a serious condition known as injection-site sarcoma (fibrosarcoma) may occur. However, the benefits of preventing a fatal viral disease far outweigh the risks in high-exposure cats.
FeLV Testing
Veterinarians use blood tests, typically ELISA, to detect FeLV. It's effective in identifying infections before symptoms appear. False positives are rare, though repeat testing may be conducted in certain cases, such as for uncertain results or in very young cats.
Managing FeLV-Positive Cats
Although there’s no cure once a cat becomes persistently infected, supportive care can help manage their quality of life. Treatment may include:
- Antibiotics to manage secondary bacterial infections
- Therapy for anemia
- Routine vet visits and indoor living to reduce infection risk
Signs of FeLV Infection
Early detection is vital. Look for these common symptoms:
- Pale gums (anemia)
- Weight loss and poor coat quality
- Gingivitis and chronic diarrhea
- Recurring respiratory or urinary tract infections
- Enlarged lymph nodes and persistent fever
Looking Forward
Thanks to vaccination, improved testing, and trends toward indoor lifestyles, FeLV infections have declined. But the virus remains a danger to unvaccinated and at-risk feline populations.
Key strategies to prevent FeLV infection include:
- Vaccinating all kittens and at-risk adult cats
- Testing new cats before integrating them into households
- Providing enriched, indoor lifestyles to limit exposure
The FeLV vaccine is a vital measure to protect your cat’s long-term health and well-being. Talk to your veterinarian about your cat’s risk profile and ensure they’re properly tested and vaccinated.





