Understanding Solensia: A New Option for Feline Osteoarthritis Pain
Solensia (frunevetmab) stands out as the first FDA-approved medication designed specifically to control pain from osteoarthritis in cats. For years, managing chronic joint pain in felines has challenged both pet owners and veterinarians, but Solensia introduces a novel approach that targets the underlying mechanisms of discomfort.
What Is Osteoarthritis in Cats?
Osteoarthritis is a degenerative joint condition where cartilage gradually breaks down. As this protective tissue erodes, bones begin to rub together, causing persistent pain, stiffness, and reduced mobility. Cats are masters at hiding discomfort, so the signs can be subtle:
- Reluctance or difficulty jumping onto furniture
- Avoiding stairs
- Lethargy or decreased activity
- Lameness in one or more legs
- Stiff or swollen joints
- Less grooming and decreased interest in play
If you notice any of these behaviors, especially in an older cat, it's worth discussing with your veterinarian.
The Challenge of Pain Management in Cats
Treating chronic pain in cats isn't simple. Traditional medications like nonsteroidal anti-inflammatory drugs (NSAIDs) can cause kidney damage if used long-term, leaving few safe options. Some veterinarians have tried off-label drugs such as gabapentin or tramadol, but these aren't specifically approved for feline arthritis and may not always be effective.
How Does Solensia Work?
Solensia is an injectable monoclonal antibody therapy—meaning it uses lab-made proteins to target specific molecules involved in disease processes. The active ingredient, frunevetmab, binds to nerve growth factor (NGF), a protein that plays a key role in transmitting pain signals from arthritic joints. By neutralizing NGF, Solensia interrupts these signals before they reach the brain, reducing your cat's perception of pain and potentially improving mobility and comfort.
Administration and Dosage
- Solensia is given as a subcutaneous injection (under the skin) once a month.
- A veterinarian or licensed technician administers the shot; it's not intended for home use.
- The dose depends on your cat's weight—cats above or below about 15.4 lbs receive different amounts.
Your veterinarian will determine the right dosage and schedule. If your cat misses an injection, contact your clinic to reschedule promptly.
Efficacy: What Can You Expect?
Clinical studies showed that more than 75% of cats treated with Solensia experienced noticeable improvement in pain and mobility within three months. Some owners reported changes as soon as two to three weeks after starting therapy—though every cat responds differently.
Side Effects and Safety Considerations
- Mild side effects are most common: vomiting, diarrhea, mild injection site reactions (pain or scabbing), irritated skin.
- Serious allergic reactions such as anaphylaxis are rare but possible; signs include swelling, trouble breathing, or collapse—seek immediate veterinary care if these occur.
Certain cats shouldn't receive Solensia:
- Cats who are pregnant, breeding, or lactating
- Cats with known allergies to frunevetmab
The safety of Solensia hasn't been established for kittens under 12 months old or those weighing less than 5.5 lbs.
How Does It Compare to Other Treatments?
The main advantage of Solensia is its targeted mechanism—by focusing on NGF rather than inflammation alone, it avoids systemic impacts on organs like the liver and kidneys (a major concern with NSAIDs). It's also tailored specifically for cats rather than being adapted from human or canine medicine.
Supportive Care Remains Important
While Solensia can significantly reduce pain and improve quality of life for many cats with osteoarthritis, it's not a cure. Supportive measures still matter:
- Maintain a healthy weight—extra pounds put more strain on joints.
- Add ramps or steps so your cat can access favorite spots without jumping.
- Provide soft bedding for comfort.
Your veterinarian may also recommend joint supplements or other therapies alongside Solensia.
Storage and Handling
- The medication must be kept refrigerated by your veterinary clinic and protected from light until use.
If you're pregnant or breastfeeding—or trying to conceive—you should avoid handling Solensia due to potential allergic reactions if accidentally injected.
Cost and Availability
- The price per injection typically ranges from $60 to $115 depending on region and veterinary fees; costs may be higher for larger cats due to dosing requirements.
Certain pet insurance plans might cover all or part of the expense—ask your provider about coverage options if cost is a concern. In the United States, Solensia became available after FDA approval in January 2022; it's also approved in Europe since 2021.
A New Era for Feline Arthritis Care
If your cat has been diagnosed with osteoarthritis—or you suspect they might be suffering—talk with your veterinarian about whether Solensia could help. Regular wellness checks remain crucial even after starting treatment; combine medication with environmental adjustments for best results. With careful management and new options like Solensia now available, many cats can enjoy greater comfort well into their senior years.
