Understanding the Difference Between Bravecto and Credelio for Cats
When it comes to protecting your feline companion from fleas and ticks, two commonly prescribed medications are Bravecto and Credelio. Both are effective options approved by the FDA for use in cats, but they differ in several key aspects, such as administration frequency, active ingredients, and safety considerations. Choosing the right product can depend on your cat’s age, health status, and lifestyle. This article explores the differences to help you make an informed decision.1. Active Ingredients and Mechanism of Action
- Credelio contains lotilaner, an isoxazoline class insecticide that kills fleas and ticks by targeting GABA-gated chloride channels in their nervous systems. Lotilaner offers monthly protection.
- Bravecto for cats contains fluralaner, also an isoxazoline, with a longer activity duration. A single dose typically provides up to 12 weeks of protection against fleas and certain ticks.
2. Dosing Frequency
- Credelio: Administered every 30 days. It begins killing fleas within 6 hours and shows over 97% tick-killing efficacy within 72 hours, maintained for one month.
- Bravecto: Given once every 12 weeks, offering longer-lasting protection with fewer administrations.
3. Indications and Coverage
- Credelio is FDA-approved for cats and kittens 8 weeks and older (at least 2 lbs) for flea prevention, and for black-legged tick control in cats at 6 months and older.
- Bravecto typically targets a broader range of tick species and may also help control mites depending on the formulation.
4. Administration
- Credelio is a small, flavored, chewable tablet, administered with food for optimal absorption.
- Bravecto for cats comes in two forms: an oral chewable and a topical solution. The topical is ideal for cats that resist oral medication.
5. Safety and Side Effects
- Both products belong to the isoxazoline drug class and carry similar rare risks of neurologic side effects like tremors or seizures, especially in animals with pre-existing conditions.
- Credelio: May cause vomiting, diarrhea, weight loss, increased respiratory rate, or reduced appetite. These effects usually resolve after the drug leaves the system.
- Bravecto: Also linked to rare gastrointestinal and neurologic side effects, but considered safe when used according to label instructions.
6. Age and Weight Restrictions
- Credelio is approved for kittens 8 weeks and older, weighing at least 2 lbs. For tick control, the minimum age is 6 months.
- Bravecto is generally approved for kittens 6 months and older, depending on product formulation and regional guidelines.
7. Storage and Handling
- Credelio should be stored in original blister packaging at controlled room temperature (59–77°F).
- Bravecto storage requirements vary based on its dosage form but are similarly convenient for pet owners.
8. Drug Interactions
- Credelio has shown no significant interactions with vaccines, antibiotics, NSAIDs, or anesthetics.
- Bravecto has a similar interaction safety profile but always consult a vet before combining with other isoxazoline products.
9. Veterinary Recommendation
While both products are prescription-based, only a veterinarian can determine which option best suits your cat’s health and lifestyle. Cats with a history of seizures or neurologic disorders may require alternative flea and tick preventatives.
10. Final Thoughts
Choosing between Bravecto and Credelio depends largely on your preference for dosing frequency and your cat’s specific needs. Monthly administration with Credelio may be preferable for easier monitoring of side effects, while Bravecto’s longer action may benefit owners seeking convenience.
Ultimately, both Credelio and Bravecto provide effective control of fleas and ticks and can help protect your cat from parasite-related diseases year-round.





