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What can cause pyometra in cats?

Pyometra in cats is caused by a bacterial infection of the uterus, typically following hormonal changes after estrus that lead to thickening of the uterine lining and create an environment prone to infection.

Understanding Pyometra in Cats: Causes, Symptoms, and Prevention

Pyometra is a serious and potentially fatal condition affecting female cats. It involves the accumulation of pus within the uterus and typically develops due to hormonal changes after the estrus (heat) cycle. While more commonly discussed in dogs, feline pyometra deserves equal attention due to its severity and the rapid progression of clinical symptoms.

What Causes Pyometra in Cats?

The primary cause of pyometra is a bacterial infection, most commonly involving Escherichia coli (E. coli) and other opportunistic organisms that ascend from the vagina into the uterus. The root of the condition lies in the cat’s hormonal cycle:
  • Progesterone Influence: After the estrus phase, elevated progesterone levels cause the uterine lining to thicken in preparation for potential pregnancy.
  • Cystic Endometrial Hyperplasia: If pregnancy does not occur, repeated exposure to progesterone leads to abnormal growth of the uterine lining, a condition called cystic endometrial hyperplasia, which creates a fertile environment for bacterial growth.
  • Secondary Infection: Bacteria can gain access during or after estrus when the cervix is open, leading to a uterine infection.
Other risk factors include:
  • Age: Middle-aged to older, unspayed cats are at higher risk.
  • Repeated Heat Cycles: Queens that are not bred and repeatedly go through heat cycles face increased hormonal exposure and endometrial changes.
  • Hormonal Treatments: Use of certain hormone injections to control estrus may predispose cats to pyometra.

Types of Pyometra

There are two primary forms of feline pyometra:
  1. Open Pyometra: The cervix remains open, allowing pus to drain through the vulva. Owners may notice a foul-smelling vaginal discharge.
  2. Closed Pyometra: The cervix is closed, preventing drainage. This is a more dangerous form as the infection and pressure can build up within the uterus, increasing the risk of sepsis or uterine rupture.

Clinical Signs of Pyometra in Cats

Recognizing symptoms early is crucial:
  • Lethargy
  • Loss of appetite
  • Fever
  • Vomiting and diarrhea
  • Increased thirst and urination (especially in dogs, occasionally in cats)
  • Abdominal distension
  • Vaginal discharge (in open pyometra)

Diagnosis and Treatment

Veterinarians diagnose pyometra based on:
  • Clinical history and symptoms
  • Physical examination: Palpation may reveal an enlarged, fluid-filled uterus.
  • Imaging: Ultrasound or radiographs to visualize the uterus.
  • Blood tests: Often show elevated white blood cell count and signs of systemic inflammation.
Treatment options include:
  • Emergency spay (ovariohysterectomy): The most effective and definitive treatment.
  • Medical management: In select cases (valuable breeding cats), hormonal therapy with antibiotics may be attempted but carries a risk of recurrence and incomplete resolution.

Prognosis and Recovery

When treated promptly with surgery, the prognosis is generally good. However, delayed diagnosis or treatment dramatically increases the risk of complications such as septicemia or uterine rupture. Post-operative care includes antibiotics, fluids, and pain management.

Prevention of Pyometra in Cats

The most effective way to prevent pyometra is spaying your cat before the first or second heat cycle. This removes the uterus and ovaries, eliminating hormonal cycling and the risk of uterine infections. Preventative tips include:
  • Spaying any cat not intended for breeding
  • Avoiding overuse of hormonal estrus suppression treatments
  • Monitoring unspayed cats closely after heat cycles

Conclusion

Pyometra is a grave but preventable condition in female cats. Understanding its hormonal basis and watching for early clinical signs can save your pet’s life. Talk to your veterinarian about safe spaying practices, especially for cats not planned for breeding. Early veterinary attention is crucial for any signs of illness in intact females.

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