Background
  1. Home
  2. News
  3. FAQ
  4. What dogs should not take NexGard?

What dogs should not take NexGard?

Dogs with a history of seizures or neurologic disorders, or those who are breeding, pregnant, or lactating, should not take NexGard without veterinary supervision.

Which Dogs Should Avoid NexGard PLUS? A Comprehensive Guide for Pet Owners

NexGard PLUS is a powerful, convenient monthly chewable that protects dogs from a range of parasites including fleas, ticks, heartworms, roundworms, and hookworms. While it's an effective treatment for many dogs, there are specific cases where NexGard PLUS may not be suitable. Understanding the precautions and safety considerations can help pet owners make informed decisions in consultation with their veterinarian.

Key Ingredients and Their Roles

NexGard PLUS combines three active ingredients:
  • Afoxolaner: Kills adult fleas and ticks.
  • Moxidectin: Prevents heartworm disease by eliminating larvae.
  • Pyrantel: Treats and controls hookworm and roundworm infections.
These ingredients bring together broad-spectrum protection but also require careful administration under appropriate circumstances.

Dogs That Should Avoid NexGard PLUS

1. Dogs with a history of seizures or neurologic disorders
Afoxolaner is part of the isoxazoline class, which has been associated with neurologic side effects such as tremors, ataxia (loss of coordination), and seizures. While these reactions are relatively rare, dogs with pre-existing neurologic issues should only use the product with veterinary supervision. 2. Pregnant, breeding, or lactating dogs
The safety of NexGard PLUS in pregnant, breeding, or nursing dogs has not been evaluated. Consequently, it's best to avoid use in these populations unless otherwise advised by a veterinarian. 3. Dogs under 8 weeks old or less than 4 pounds
NexGard PLUS is only approved for puppies and adult dogs that are at least 8 weeks old and weigh 4 pounds or more. Giving the medication to dogs outside this range may result in inappropriate dosing and potential adverse effects. 4. Dogs with an existing adult heartworm infection
While NexGard PLUS prevents heartworm disease, it is not effective against adult Dirofilaria immitis (mature heartworms). Dogs must be tested for current heartworm infections before starting the medication.

Common Side Effects and Reactions

In clinical trials, the most commonly reported adverse reactions included:
  • Vomiting
  • Diarrhea
  • Lethargy
  • Itching
While these side effects are generally mild and temporary, pet owners should monitor their dog closely after administration.

Important Administration Notes

  • NexGard PLUS should be given once a month on the same day each month.
  • It can be given with or without food.
  • If a dog vomits within two hours of administration, a replacement dose may be necessary.
  • Never store a partially used chew; single-use only.

Veterinary Supervision Is Key

All dogs should have a veterinary exam and a heartworm test before beginning NexGard PLUS. Even if a dog seems healthy, a background of medical issues may present unseen risks when using preventive medications. Veterinarians may recommend alternative treatments or conduct additional tests based on your dog’s medical history.

Dogs That Can Safely Use NexGard PLUS

NexGard PLUS is safe for most dogs that:
  • Are 8 weeks of age or older
  • Weigh at least 4 pounds
  • Have no history of neurologic symptoms
  • Are not pregnant or nursing
It has been proven effective and well-tolerated in a wide variety of dog breeds. Most owners find it convenient, especially when used as part of a regular monthly health routine.

Concurrent Medications

In clinical studies, NexGard PLUS was safely used alongside common medications such as:
  • Vaccines
  • Antibiotics
  • Anti-inflammatories
  • Anaesthetics
  • Steroids
  • Antiparasitics
This compatibility makes it a practical choice for most domestic dogs.

Summary

NexGard PLUS offers comprehensive protection against several common parasites in dogs with the ease of a monthly chew. However, it is not suitable for every pet. Avoid giving NexGard PLUS to dogs with a known history of seizures, pregnant or lactating females, puppies under 8 weeks old or below 4 pounds, or dogs with existing adult heartworm infections. Always consult with a veterinarian before beginning treatment to ensure your pet’s safety. With the right veterinary guidance, NexGard PLUS can be a valuable part of your pet's preventive care plan.

Share on:

nexgard plus

 dogs and nexgard

 nexgard safety

 can dogs take nexgard

 nexgard for puppies

 seizures in dogs

 dog parasite prevention

 tick prevention for dogs

 flea medications

 oral flea protection

 heartworm prevention

 dog weight nexgard

 safe dog medicine

 pregnant dog medication

 nursing dog treatment

 neurological issues in dogs

 hookworm control

 roundworm prevention

 isoxazoline safety

 moxidectin use

 pyrantel in dogs

 monthly dog chews

 dog medication guidelines

 vet recommended flea control

 pet owner guide

Recommended

Marine Mammals of Maine team rescuing and caring for a harbor seal pup

Marine Mammals of Maine Leads Seal Rehabilitation Efforts with Over 300 Animal Responses in 2025

Read the article

Small Shih Tzu dog resting on beige ottoman with colorful toys indoors

Going on Vacation Without Your Dog: How to Handle the Guilt

Read the article

Happy person with their emotional support dog providing comfort

Understanding Emotional Support Animals: Your Complete Guide to ESA Benefits and Requirements

Read the article

Today is the perfect time to get your

Pet Health Report

Upload a photo of your pet to receive instant health and care insights.

report_card