Understanding the Controversy Around Seresto Flea Collars
The Seresto flea collar, a popular product for flea and tick prevention in dogs and cats, has been under regulatory scrutiny following reports of adverse effects and even pet deaths. More than 70 million Seresto collars have been sold globally, providing up to 8 months of protection with its two active ingredients: imidacloprid and flumethrin. Despite its success, concerns have arisen that prompted a deep investigation by the U.S. Environmental Protection Agency (EPA).
The Source of the Controversy
In 2021, the EPA launched a comprehensive review due to a large number of incident reports, including 1,400 pet deaths reported between 2016 and 2020. However, critical report details were often incomplete, making it difficult to determine causation. In many cases, deaths were attributed to mechanical strangulation or collar-related trauma rather than the chemicals themselves.
Reported Adverse Reactions
- Skin irritation
- Hair loss at application site
- Neurological symptoms like ataxia or seizures
- In non-lethal cases, symptoms often subsided after collar removal
Reviewers determined that the rate of serious incidents was comparable to other pet products. In many cases, reactions were mild and temporary.
EPA's Regulatory Response
The EPA has mandated several new safety protocols for Seresto collars:
- Updated warning labels including guidance for symptom recognition and reporting
- Improved incident data collection and follow-ups regarding pet health history
- Annual reporting of incidents and sales
- Evaluation of the collar’s release mechanism to minimize strangulation risks
- Five-year continued registration pending further incident evaluations
Elanco’s Position on Safety
Elanco Animal Health, Seresto’s manufacturer, maintains that their data shows a very low incidence rate of adverse effects – less than 0.2% in recent years. The company claims that reported cases rarely involve the collar’s active ingredients. When used properly, they argue, the product is safe and effective.
Authenticity Matters
Health professionals and the Pet Poison Helpline warn of counterfeit products sold online, which show a higher rate of complications. They recommend purchasing the collar only from veterinary offices or trusted retailers to ensure authenticity and safety.
Guidance for Pet Owners
Veterinarians generally continue to support year-round flea and tick prevention, recognizing that the risks of vector-borne diseases often outweigh the rare side effects of collars like Seresto.
Best practices for using Seresto:
- Monitor your pet for the first few days after application
- Remove the collar immediately if symptoms appear
- Consult your veterinarian for alternatives if your pet has a history of skin reactions
- Purchase only from authorized sources to avoid counterfeits
- Use as directed—follow labeling instructions carefully
Effectiveness Remains a Strong Point
Feedback from pet owners and vets indicates that Seresto collars are highly effective against fleas and ticks. The polymer matrix design allows for slow release of ingredients across the pet’s skin and coat and is water-resistant, although frequent bathing can reduce its effectiveness.
Special Populations and Additional Cautions
Use in pregnant or lactating animals remains a debated issue. While the chemicals work on the skin’s fatty layer and don’t enter the bloodstream, the manufacturer advises veterinary consultation before use in these groups.
Conclusion
The Seresto flea collar continues to be one of the most widely used and effective products on the market. While thousands of pets benefit from its prevention power, a small number may experience adverse reactions. With proper usage, awareness of signs, and reliable sourcing, many experts believe the benefits outweigh the potential risks.





