Understanding the Difference Between NexGard PLUS and Regular NexGard
When it comes to protecting your dog from parasites, choosing the right medication is crucial. Two commonly used options are NexGard and NexGard PLUS, both offering effective parasite control—but with notable differences. While both products share a similar name and some active ingredients, they offer varying levels of protection. Knowing the distinction can help ensure your pet receives comprehensive coverage against the parasites most likely to affect their health.
Key Active Ingredients
NexGard contains only
afoxolaner, which is effective against adult fleas and ticks.
NexGard PLUS includes three active ingredients:
- Afoxolaner: Kills fleas before they can lay eggs and eliminates four types of ticks commonly found in the U.S.
- Moxidectin: Prevents heartworm disease by eliminating larvae of Dirofilaria immitis acquired in the prior month.
- Pyrantel: Treats and controls hookworm and roundworm infections.
Parasite Coverage
NexGard:
- Effective only against fleas and ticks
NexGard PLUS:
- Protects against fleas and ticks (same as NexGard)
- Prevents heartworm disease
- Treats and controls roundworms and hookworms
Usage and Administration
Both products are administered orally as beef-flavored chewables and are given once a month. However, NexGard PLUS offers multi-parasite protection with a single monthly dose.
Dosage for NexGard PLUS is based on weight and includes specific ingredient amounts for different ranges:
- 8.1-17 lbs: 18.75 mg afoxolaner, 90 mcg moxidectin, 37.5 mg pyrantel
- 17.1-33 lbs: 37.5 mg afoxolaner, 180 mcg moxidectin, 75 mg pyrantel
- 33.1-66 lbs: 75 mg afoxolaner, 360 mcg moxidectin, 150 mg pyrantel
- 66.1-132 lbs: 150 mg afoxolaner, 720 mcg moxidectin, 300 mg pyrantel
For dogs above 132 lbs, a suitable combination of chewables is recommended.
Effectiveness and Timing
Both products:
- Begin killing fleas within 4 hours
- Show over 99% flea efficacy at 8 hours post-treatment
Tick efficacy (NexGard PLUS):
- >97% against American dog ticks
- >94% against black-legged ticks
- >93% against brown dog ticks
These levels of protection continue for a full month post-dosing.
Pediatric Safety and Administration Notes
NexGard PLUS is safe for puppies aged 8 weeks and older, as long as they weigh at least 4 pounds. It may be administered with or without food. If your dog vomits within two hours of ingestion or fails to consume the full dose, a replacement dose should be given.
Additional Benefits of NexGard PLUS
- Protects against heartworm disease when used regularly
- Controls intestinal parasites such as roundworms and hookworms
- One chewable simplifies monthly dosing compliance
- Compatible with most commonly prescribed medications
Precautions
- Not for human use—keep out of reach of children
- Do not use in dogs with known sensitivities to isoxazolines
- Use caution in dogs with a history of seizures or neurologic issues
- Not evaluated in breeding, pregnant, or lactating dogs
- Test for heartworm prior to initiation
Veterinary & Owner Guidance
Veterinarians recommend year-round parasite prevention due to ongoing exposure risks. While many dogs find NexGard PLUS palatable, if your dog resists, the chew can be broken and hidden within food. Monitor your pet for signs of side effects, including vomiting, diarrhea, lethargy, or itching. In rare cases, neurologic symptoms such as tremors or seizures may occur.
Summary: Which Should You Choose?
If your goal is to prevent fleas and ticks only, regular NexGard may suffice. However,
NexGard PLUS is the better option for
comprehensive parasite protection, covering both external and internal threats in one convenient chew. Always consult with your veterinarian to determine the best option for your dog’s needs and health history.
