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Why has my cat still got fleas after using Frontline?

Fleas may still appear after using Frontline because newly acquired pests from the environment can jump onto your cat, but they will be killed within 24 hours.

Why Your Cat May Still Have Fleas After Using Frontline

Many cat owners expect immediate, complete results after applying a flea treatment like Frontline Plus. However, seeing a few fleas even after treatment is not necessarily a failure of the product. Understanding how Frontline Plus for Cats works and the details of flea biology is crucial to managing expectations and resolving infestations effectively.

How Frontline Plus Works

Frontline Plus is a topical treatment applied directly to your cat's skin, usually between the shoulder blades. It contains two active ingredients:

  • Fipronil — kills adult fleas and ticks by disrupting their central nervous system. It typically kills fleas within 24 hours and ticks within 48 hours.
  • (S)-methoprene — an insect growth regulator that prevents flea eggs, larvae, and pupae from developing into adults.

This dual-action approach treats current infestations and halts the flea life cycle to prevent future outbreaks.

Common Reasons Fleas Persist After Treatment

  1. New Fleas from the Environment: Even post-application, fleas from carpets, bedding, or outdoors can jump onto your cat. These will die within 24 hours due to the active ingredients, but their presence may give the illusion that treatment failed.
  2. Inadequate Environmental Control: Treating the cat alone is not enough if the household isn’t cleaned thoroughly. Flea eggs and larvae in carpets, upholstery, and bedding can develop into adults and re-infest your pet.
  3. Improper Application: If Frontline Plus isn't applied correctly (e.g., not on the skin or not the full contents), its effectiveness may diminish. Proper administration ensures the product spreads via sebaceous glands across the skin and coat.
  4. Inconsistent Use: A single dose won't clear a well-established infestation. Monthly application is essential to break the flea life cycle and prevent recurrence.
  5. Bathing Too Soon: If your cat is bathed within 24–48 hours after application, the medication may not absorb properly or be washed off prematurely.
  6. Cross-grooming by Pets: If cats groom each other before the application site dries, it can reduce the effectiveness or lead to ingestion, which might cause side effects.

Steps to Effectively Eliminate Fleas

  • Treat All Pets: Every pet in the household should be treated with flea products appropriate for their species and size.
  • Clean the Environment: Vacuum regularly, especially in pet-frequented areas. Wash pet bedding at high temperatures.
  • Use Consistently: Apply Frontline Plus once a month year-round, even if your cat lives indoors. Fleas can hitchhike indoors via humans, other animals, or objects.
  • Wait and Observe: It may take several weeks of consistent treatment to fully eliminate a flea infestation in the home.

When to Consult Your Veterinarian

While rare, side effects such as irritation at the application site, drooling, or in rare cases, vomiting and tremors, can occur. If you notice any of these symptoms, or if the infestation persists despite proper treatment and environmental control, consult your veterinarian. In severe cases, professional pest control may be required to treat the home environment.

Using Frontline Plus Safely

  • Only use cat-specific Frontline products; do not use dog formulations.
  • Never split one pipette between multiple pets.
  • Store Frontline Plus at room temperature, away from sunlight and out of reach of children and other animals.
  • Wait 24 hours before touching the application site and prevent your cat from grooming until it's dry.

Conclusion

Frontline Plus is a reliable and effective treatment for fleas, but it must be used correctly and consistently—with simultaneous environmental management—to resolve infestations entirely. Patience and persistence are key to keeping your cat flea-free.

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