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Acepromazine typically makes dogs feel sedated and calm, but it does not relieve anxiety and may cause some anxious pets to feel more distressed due to reduced mobility.
Trazodone and acepromazine may be used together in dogs under veterinary supervision, but combining them can increase sedation and side effects.
Acepromazine makes dogs feel sedated and calm by depressing the central nervous system, but it does not relieve anxiety and may cause distressed dogs to feel immobilized.
Trazodone and acepromazine may be used together in dogs under strict veterinary supervision, as both have sedative effects and can enhance each other's actions.
Acepromazine makes dogs feel sedated and less reactive to stimuli, though it may not relieve anxiety and can sometimes make nervous dogs feel worse due to decreased mobility.
The most common side effect of acepromazine is sedation.
Boxers, Greyhounds, Sighthounds, and dogs with the MDR1 mutation (e.g., Collies, Shetland Sheepdogs, Australian Shepherds) are especially sensitive to acepromazine.
Acepromazine usually wears off in dogs within one to eight hours, but effects can last longer in animals with liver or kidney disease.
Trazodone is generally preferred over acepromazine for anxiety-related conditions in dogs, as it has mild sedative and true anti-anxiety effects, unlike acepromazine.
Acepromazine is used in dogs as a tranquilizer and sedative for procedures, travel, or to control agitation, and as a pre-anesthetic or antiemetic.

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